Are you looking for best cold and flu medicine, we’ve consulted top experts who has in-and-out knowledge about the cold and flu medicine. We choose the top most quality product, which comes with amazing features you’ve never heard before. We have filter more than 100+ of product to give you top 10 list of best cold and flu medicine.

This list is undoubtedly the best cold and flu medicine available in the market today. However, if you don’t want to spend more time on filtering and finding which one is good cold and flu medicine, then you should absolutely go for our Top list of the winner. which comes with all the basic features one could expect in a cold and flu medicine.


Best cold and flu medicine – The Winners!


But these three has some more competitions too, Check out below List of Top 10 best cold and flu medicine.If you are ready to choose a new cold and flu medicine, check out our recommendations for the best cold and flu medicine. But if you’d like to learn more about the various types of cold and flu medicine available and how to choose the right one for you, read on.

List of Top 10 Best cold and flu medicine In Detailed


SaleBestseller No. 1
Tylenol Cold + Flu Severe Day & Night Caplets for Fever, Pain, Cough & Congestion Relief, 24 Count
  • 24-count combo pack of Tylenol Cold + Flu Severe Day/Night Caplets for multi-symptom cold and flu symptom relief. From the #1 doctor recommended pain relief brand, the combo pack includes 16 Daytime and 8 Nighttime caplets for relief any time of the day
  • The Daytime relief caplets are formulated to reduce fever, loosen phlegm and relieve headache, body aches, cough, sore throat, nasal congestion and chest congestion
  • The Nighttime relief caplets help reduce fever and relieve runny nose, sneezing, headache, cough, sore throat, nasal congestion, sinus congestion and pressure
  • Each cold & flu caplet contains 325 mg of acetaminophen, a pain reliever and fever reducer; 5 mg of phenylephrine HCl, a nasal decongestant; and 10 mg of dextromethorphan HBr, a cough suppressant
  • The Daytime caplets also contain guaifenesin 200 mg, an expectorant to help loosen phlegm (mucus) to make coughs more productive. The Nighttime caplets also contain 2 mg of chlorpheniramine maleate, an antihistamine.
SaleBestseller No. 2
Vicks DayQuil and NyQuil Severe, Cough, Cold, Flu, Sore Throat, Fever, and Congestion Day and Night Relief, Maximum Strength, Green & Red, 48 Count (32 DayQuil + 16 NyQuil)
  • MAXIMUM STRENGTH COLD & FLU RELIEF. DayQuil/NyQuil SEVERE delivers maximum symptom-fighting ingredients to relieve your worst cold & flu symptoms, such as cough, sore throat, fever, and congestion, day or night
  • SMALLEST BRANDED, 4-ACTIVE, MAXIMUM STRENGTH DAYTIME LIQUICAPS. DayQuil SEVERE offers non-drowsy relief of your cold and flu symptoms, so you can power through your day. Guaifenesin helps Loosen Phlegm (Mucus) And Thin Bronchial Secretions To Rid The Bronchial Passageways Of Bothe
  • OUR SMALLEST MOST POWERFUL NIGHTTIME LIQUICAP. NyQuil SEVERE relieves your sneezing, sore throat, headache, minor aches & pains, fever, runny nose, and cough, so you can get the rest you need
  • PAIN RELIEF & FEVER REDUCER. DayQuil/NyQuil SEVERE is an over-the-counter medicine that contains acetaminophen, a pain reliever and fever reducer that can help soothe sore throat
  • MULTI-SYMPTOM RELIEF with NyQuil SEVERE Cold & Flu, which also contains a nasal decongestant and DayQuil SEVERE Cold & Flu, which contains an expectorant to help loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive
SaleBestseller No. 3
Amazon Basic Care Cold Flu Relief Multi-Symptom Daytime Night time Combo Pack Softgels; Cold Medicine, Nitetime: Green; Daytime: Orange, 48 Piece Assortment, 48 Count
  • ACTIVE INGREDIENTS: Compare to the active ingredients in Vicks DayQuil Cold & Flu and Vicks NyQuil Cold & Flu
  • NON-DROWSY DAYTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, nasal congestion, cough, and minor aches and pains
  • NIGHTTIME COLD AND FLU MEDICINE provides multi-symptom relief of headache, fever, sore throat, sneezing, runny nose, cough, and minor aches and pains
  • PAIN RELIEVER AND FEVER REDUCER: Both Daytime and Nighttime cold medicine contain acetaminophen to help relieve aches, fever and sore throat
  • COLD AND FLU: Influenza (flu) and the common cold are respiratory illnesses caused by viruses. A cold medicine like Cold & Flu Relief Multi-Symptom Daytime/Nighttime can help
Bestseller No. 4
Tylenol Cold + Flu Severe Daytime & Nighttime Liquid Cough Medicine, 2 ct. of 8 fl. oz
  • Value pack of Tylenol Cold + Flu + Cough Severe Liquid Medicine containing one 8-fluid ounce bottle of non-drowsy daytime relief medicine and one 8-fluid ounce bottle of nighttime relief medicine
  • The daytime flu relief for adults features a powerful non-drowsy formula to keep you going through waking hours with a warming honey lemon flavor. The nighttime liquid medicine relieves symptoms to help you sleep and comes in a soothing berry flavor.
  • The liquid medicines both provide temporary relief of cold & flu symptoms including fever, cough, nasal & chest congestion, head & body aches & sore throat. They also aid in loosening mucus & thinning bronchial secretions for more productive coughs
  • Formulated with acetaminophen for pain relief & fever reduction, phenylephrine HCl nasal decongestant, guaifenesin as an expectorant & dextromethorphan HBr cough suppressant. The nighttime formula also contains doxylamine succinate, an antihistamine
  • Temporarily relieve multiple symptoms both day and night with these powerful severe cold, cough, and flu medicines for adults
Bestseller No. 5
Mucinex Fast-Max Day Time Cold & Flu and Night Time Cold & Flu Medicine, Maximum Strength All in One Multi Symptom Relief for Congestion, Sore Throat, Headache, Cough and Reduces Fever, 30 Caplets
  • MUCINEX FAST-MAX: Maximum strength multi-symptom relief medicine; 1 dose treats 9 symptoms - get back to what’s important thanks to the fast, powerful relief of Mucinex
  • DAY TIME SYMPTOMS TREATED: Maximum strength day time cold and flu non-drowsy caplets relieve cough, chest, nasal & sinus congestion that can cause mucus buildup, sinus pressure, reduces fever, body pain & headache and sore throat
  • NIGHT TIME SYMPTOMS TREATED: Maximum strength night time cold and flu chaplets relieve cough, nasal congestion that leads to the stuffy nose, reduces fever, body pain & headache, sneezing, runny nose and sore & itchy throat
  • DAY TIME ACTIVE INGREDIENTS PER CAPLET: Acetaminophen - 325 mg pain reliever and fever reducer; Phenylephrine HCI - 5 mg nasal decongestant; Dextromethorphan HBr - 10 mg cough suppressant; Guaifenesin - 200 mg expectorant/thins and loosens mucus
  • NIGHT TIME ACTIVE INGREDIENTS PER CAPLET: Acetaminophen - 325 mg pain reliever and fever reducer; Phenylephrine HCI - 5 mg nasal decongestant; Diphenhydramine HCI - 12.5 mg cough suppressant/antihistamine
  • CONVENIENT CAPLETS: 20 day time and 10 night time caplets; adults and children 12 years of age and older, take 2 caplets every 4 hours
SaleBestseller No. 6
Tylenol Cold + Flu Severe Medicine Caplets for Fever, Pain, Cough & Congestion, 24 ct.
  • 24-count of Tylenol Cold + Flu Severe Pain Reliever & Fever Reducer Medicine Caplets provide effective relief of multiple symptoms due to the flu and common cold
  • This severe cold & flu medicine helps relieve fever, headache, minor aches and pains, sore throat, nasal congestion, and cough. It also helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive.
  • Each caplet contains 325 mg of acetaminophen to help reduce fever and relieve minor aches & pains, as well as 10 mg of the cough suppressant dextromethorphan HBr to help quiet coughs
  • Each caplet also contains 5 mg of the nasal decongestant phenylephrine HCl to help relieve congestion and 200 mg of the expectorant guaifenesin to help loosen phlegm (mucus) and make coughs more productive
  • From the #1 doctor-recommended pain relief brand, this cold & flu medicine is suitable for use by adults and children 12 years and older for powerful multi-symptom relief
SaleBestseller No. 7
Vicks DayQuil and NyQuil SEVERE, Liquid Cough, Cold and Flu Relief, Sore Throat, Fever, and Congestion Relief, Day and Night Relief, Berry Flavor, 12 FL OZ Day and Night Pack
  • MAXIMUM STRENGTH COLD & FLU RELIEF. DayQuil/NyQuil SEVERE delivers temporary relief to your toughest cold & flu symptoms, such as cough, sore throat, fever, and congestion, day or night
  • MAXIMUM SYMPTOM-FIGHTING INGREDIENTS to relieve your worst cold & flu symptoms, among OTC cold & flu medicines
  • DAYQUIL SEVERE NON-DROWSY, DAYTIME RELIEF. Temporarily relieves common cold & flu symptoms, including nasal congestion, cough due to minor throat and bronchial irritation, sore throat, headache, minor aches & pains, and fever
  • NYQUIL NIGHTTIME RELIEF. Temporarily relieves common cold & flu symptoms, including cough due to minor throat and bronchial irritation, sore throat, headache, minor aches and pains, fever, runny nose and sneezing so you can sleep
  • MULTI-SYMPTOM RELIEF with NyQuil SEVERE Cold & Flu, which also contains a nasal decongestant and DayQuil SEVERE Cold & Flu, which contains an expectorant to help loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive
SaleBestseller No. 8
Vicks NyQuil SEVERE, Nighttime Relief of Cough, Cold & Flu Relief, Sore Throat, Fever, & Congestion Relief, Berry Flavor, Twin Pack, 12 FL OZ
  • MAX STRENGTH NIGHTTIME RELIEF. NyQuil SEVERE Cold & Flu Liquid temporarily relieves common cold & flu symptoms, including cough due to minor throat & bronchial irritation, sore throat, headache, minor aches & pains, fever, runny nose & sneezing
  • MAXIMUM SYMPTOM-FIGHTING INGREDIENTS to relieve your worst cold & flu symptoms, among OTC cold & flu medicines
  • FROM THE WORLD’S #1 SELLING COUGH & COLD BRAND. Vicks NyQuil SEVERE helps dry up your nasal passages to relieve your runny nose
  • MULTI-SYMPTOM RELIEF. NyQuil SEVERE Cold & Flu contains a nasal decongestant for your toughest nasal congestion and sinus pressure
  • CONTAINS ACETAMINOPHEN: A pain reliever/fever reducer than can help soothe your sore throat
SaleBestseller No. 9
Mucinex Fast-Max Day Time Cold & Flu and Night Time Cold & Flu Liquid Medicine, 12 fl oz, Maximum Strength All in One Multi Symptom Relief for Congestion, Sore Throat, Headache,Cough and Reduces Fever
  • MUCINEX FAST-MAX: Maximum strength multi-symptom relief medicine; 1 dose treats 9 symptoms - get back to what’s important thanks to the fast, powerful relief of Mucinex
  • DAY TIME SYMPTOMS TREATED: Maximum strength day time cold and flu non-drowsy liquid relieves cough, chest, nasal & sinus congestion that can cause mucus buildup, sinus pressure, fever, body pain & headache and sore throat
  • NIGHT TIME SYMPTOMS TREATED: Maximum strength night time cold and flu liquid relieves cough, nasal congestion that leads to stuffy nose, fever, body pain & headache, sneezing, runny nose and sore & itchy throat
  • DAY TIME ACTIVE INGREDIENTS per 20 mL: Acetaminophen - 650 mg pain reliever and fever reducer; Phenylephrine HCI - 10 mg nasal decongestant; Dextromethorphan HBr - 20 mg cough suppressant; Guaifenesin - 400 mg expectorant/thins and loosens mucus
  • NIGHT TIME ACTIVE INGREDIENTS per 20 mL: Acetaminophen - 650 mg pain reliever and fever reducer; Phenylephrine HCI - 10 mg nasal decongestant; Diphenhydramine HCI - 25 mg cough suppressant/antihistamine
  • FAST ACTING LIQUID: 2 bottles 6 fl oz each; adults and children 12 years of age and older, 20 ml in provided dosing cup every 4 hours
  • TRUST MUCINEX: Mucinex is the No.1 Cold & Cough Brand Doctors Trust for Themselves & Their Families
SaleBestseller No. 10
Alka-seltzer Plus Cold & Flu, Power Max Cold and Flu Medicine, Day +Night, For Adults with Pain Reliever, Fever Reducer, Cough Suppresant, Nasal Decongestant, Antihistamine, 24 Count
  • NEW 25% smaller pill: Alka-Seltzer Plus Maximum Strength Cold & Flu PowerMax Gels have a concentrated formula in a smaller liquid gel so it's easier to swallow Than Alka-Seltzer Plus Cold & Flu Liquid Gels
  • One dose provides 4 hour day time or night time relief of cough, nasal congestion, headache & body ache, sore throat, sinus pressure, and runny nose.
  • Alka-Seltzer Plus Maximum Strength Cold & Flu PowerMax Gels Day & Night contain a pain reliever, fever reducer, cough suppressant, antihistamine, and nasal decongestant
  • Temporarily relieves these symptoms due to a cold or flu: Minor aches and pains, cough, headache, sore throat, nasal and sinus congestion, runny nose, & sneezing. Temporarily reduces fever.
  • PowerMax Gels do not have to be taken with meals.
Hope this list of the best cold and flu medicine will be helpful for you. Feel free to contact us if you have any questions about our site or our reviews, and we will be happy to help you with your purchasing decisions in any way we can.